DAILY CURRENT AFFAIRS (AUGUST 03, 2022)

THE INDIAN HISTORY

1.PINGALI VENKAYYA: THE DESIGNER OF INDIAN NATIONAL TRICOLOUR

THE CONTEXT: To mark the birth anniversary of Venkayya on August 2, the Central government has decided to release a special commemorative postage stamp on that day.

THE EXPLANATION:

  • As India marks 75 years of Independence, the Tricolour represents the sovereignty and freedom, and each colour (saffron, white and green) points at courage, truth and peace, and faith and chivalry.
  • And this Tricolour was planted by freedom fighter Pingali Venkayya. On his 126th birth anniversary, the culture ministry has organised ‘Tiranga Utsav’, and a special commemorative postage stamp honouring Venkayya will be released.

WHO IS PINGALI VENKAYYA?

Venkayya was born on August 2, 1876 at Bhatlapenumarru, near present-day Machilipatnam town in Andhra Pradesh. He completed his high school in Madras and went to Cambridge University and acquired knowledge in geology, agriculture, education and languages.

JOURNEY OF FLAG

Venkayya designed several models of national flag, starting from the one designed in 1921, which was approved by Mahatma Gandhi at a Congress meeting in Vijayawada. This version had two stripes (green and red) and Gandhian ‘charkha’ at the Centre. A white stripe was added on top at Gandhi’s suggestion, which became the original Tricolour.

THE INTERNATIONAL RELATIONS

2.LIST OF OUTCOMES: OFFICIAL VISIT OF PRESIDENT OF MALDIVES TO INDIA

THE CONTEXT: Indian Prime Minister stated that India will extend an additional $100 million line of credit to the Maldives. Following bilateral talks between PM and President of Maldives Ibrahim Mohamed Solih, India and Maldives signed six pacts to facilitate cooperation in capacity building, cyber security, housing, disaster management, and infrastructure.

THE EXPLANATION:

  • In his remarks, Mr. Solih referred to India as the “highest priority” of the Maldives and said, “Maldives-India relation, goes beyond diplomacy. Our values, our cultures and our histories are intertwined, making it a traditional relationship. Our centuries-old relationship is grown with political trust, economic cooperation and coherent strategic policies between our two countries.”

KEY TAKEAWAYS OF THE MEETING:

A.Groundbreaking/Review of Projects

  1. Pouring of first concrete of the Greater Male Connectivity Project- an USD 500 Mn India funded project- marking the commencement of permanent works.
  2. Review of the progress on the construction of 4,000 social housing units in Hulhumale being funded under Exim Bank of India Buyer’s credit finance of USD 227 Mn.
  3. Overview of India Maldives development cooperation including Addu roads and reclamation, water and sanitation in 34 islands and Friday Mosque restoration projects.

Β.Agreements/MoUs Exchanged

  1. MoU on Capacity Building & Training of Members of Local Councils & Women Development Committee of Maldives between NIRDPR, India and Local Government Authority, Maldives.
  2. MoU on Collaboration in potential fishing zone forecast capacity building and data sharing and marine scientific research between INCOIS, India and Ministry of Fisheries, Maldives.
  3. MoU for Cooperation in the area of Cyber Security between CERT-India and NCIT, Maldives.
  4. MoU for cooperation in the field of disaster management between NDMA, India and NDMA, Maldives.
  5. Agreement between EXIM Bank, India and Ministry of Finance, Maldives for USD 41 Mn Buyer’s Credit Financing of Police Infrastructure in Maldives.
  6. Letter of Intent between Exim Bank of India and Ministry of Finance, Maldives on Buyer’s Credit funding approval of USD 119 Mn for additional 2,000 social housing units to be constructed in Hulhumale. C

C.Announcements

  1. Extension of USD 100 Mn new Line of Credit to finance infrastructure projects in Maldives.
  2. Approval for award of EPC contract for the USD 128 Mn Hanimadhoo Airport Development project under Line of Credit.
  3. Approval of DPR and commencement of tendering process of the USD 324 Mn Gulhifahlu Port development project under Line of Credit.
  4. Approval of Feasibility Report and financial closure for the USD 30 Mn Cancer Hospital project under Line of Credit.
  5. USD 119 Mn Buyer’s Credit financing by Exim Bank of India for additional 2,000 social housing units in Hulhumale.
  6. Facilitation of duty free tuna exports to India from Maldives.
  7. Supply of a replacement ship for the earlier provided ship-CGS Huravee -to Maldives National Defence Force.
  8. Supply of the second Landing Craft Assault (LCA) to Maldives National Defence Force.
  9. Gifting of 24 utility vehicles to Maldives National Defence Force.

India-Maldives Relations:

  • India was first among countries, that recognised the Independent Maldives in 1965. India was also the first among countries to establish diplomatic relations with Maldives. Both the countries share linguistic, ethnic, cultural, religious and commercial ties. Maldives started its full-fledged High Commission in New Delhi in November 2004.
  • Maldives has extended its support to India, consistently, at multilateral for a like United nations, the Commonwealth, the NAM and the SAARC. India has actively aided Maldives. After the 2004 tsunami in Maldives, India was the first country send relief and aid to the Maldives.

Significance of Maldives for India:

Maldives acts as a Toll Gate for India in Indian Ocean. Maldives is situated at the southern and northern parts of island chain. It includes two important Sea Lanes of Communication, which are significant for the flow of maritime trade between Gulf of Aden and Gulf of Hormuz. Around 50% of external trade of India and 80% of India’s energy imports transit through SLOCs in Arabian Sea.

 3.UN PEACEKEEPING MISSION

THE CONTEXT: Recently the two BSF personnel who were part of the UN Peacekeeping Mission in the Democratic Republic of the Congo (DRC), were among five people killed during a protest in an eastern town near the border with Uganda.

THE EXPLANATION:

  • A total 175 Indian peacekeepers have so far died while serving with the United Nations. India has lost more peacekeepers than any other UN Member State.
  • Since 1948, UN Peacekeepers have undertaken 71 Field Missions. There are approximately 81,820 personnel serving on 13 peace operations led by UNDPO, in four continents currently. This represents a nine-fold increase since 1999.
  • A total of 119 countries have contributed military and police personnel to UN peacekeeping. Currently, 72,930 of those serving are troops and military observers, and about 8,890 are police personnel.
  • India has a long history of service in UN Peacekeeping, having contributed more personnel than any other country. To date, more than 2,53,000 Indians have served in 49 of the 71 UN Peacekeeping missions established around the world since 1948.
  • Currently, there are around 5,500 troops and police from India who have been deployed to UN Peacekeeping missions, the fifth highest amongst troop-contributing countries.
  • India has also provided, and continues to provide, eminent Force Commanders for UN Missions. India is the fifth largest troop contributor (TCC) with 5,323 personnel deployed in 8 out of 13 active UN Peacekeeping Missions, of which 166 are police personnel.
  • India’s contribution to UN Peacekeeping began with its participation in the UN operation in Korea in the 1950s, where India’s mediatory role in resolving the stalemate over prisoners of war in Korea led to the signing of the armistice that ended the Korean War. India chaired the five-member Neutral Nations Repatriation Commission, while the Indian Custodian Force supervised the process of interviews and repatriation that followed.
  • The UN entrusted the Indian armed forces with subsequent peace missions in the Middle East, Cyprus, and the Congo (since 1971, Zaire).
  • India also served as Chair of the three international commissions for supervision and control for Vietnam, Cambodia, and Laos established by the 1954 Geneva Accords on Indochina.

VALUE ADDITION:

United Nation Peacekeeping Mission:

  • United Nations Peacekeeping was created in 1948.
  • They are often referred to as Blue Berets or Blue Helmets because of their light blue berets or helmets
  • Purpose: It provides security, political, and peacebuilding support to countries under conflicts. It helps countries make the difficult, early transition from conflict to peace.
  • Principles: They are guided by three basic principles:
  1. Consent of the parties
  2. Impartiality
  3. Non-use of force except in self-defense and defense of the mandate.
  • Authorised by: Every peacekeeping mission is authorized by the UN Security Council.
  • Peacekeeping forces: Member states contribute their manpower for Peacekeeping forces on a voluntary basis.
  • Funding: The financial resources of UN Peacekeeping operations are the collective responsibility of UN Member States. Every Member State is legally obligated to pay their respective share for peacekeeping.
  • The UN Peacekeeping Force won the Nobel Peace Prize in 1988.

India and the UN Peacekeeping forces:

  • India is consistently among the top troop-contributing nations to the UN. At present, 5,528 personnel of India are serving in eight countries. It is currently the fifth-largest
  • India’s contribution to the regular budget is 0.83% and 0.16% of the peacekeeping budget.

 THE SCIENCE AND TECHNOLOGY

4.HELLFIRE R9X MISSILE

THE CONTEXT: The US military used its ‘secret weapon’ — the Hellfire R9X missile – to kill Al Qaeda chief Ayman al-Zawahiri on the balcony of a safehouse in Kabul on July 31.

THE EXPLANATION:

Al-Zawahiri, an Egyptian surgeon who had a $25 million bounty on his head, had helped coordinate the September 11, 2001, attacks that had killed nearly 3,000 people.

What is the Hellfire R9X missile?

  • Better known in military circles as the AGM-114 R9X, the Hellfire R9X is a US-origin missile known to cause minimum collateral damage while engaging individual targets.
  • Also known as the ‘Ninja Missile’, this weapon does not carry a warhead and instead deploys razor-sharp blades at the terminal stage of its attack trajectory. This helps it to break through even thick steel sheets and cut down the target using the kinetic energy of its propulsion without causing any damage to the persons in the general vicinity or to the structure of the building.

The blades pop out of the missile and cut down the intended target without causing the massive damage to the surroundings which would be the case with a missile carrying an explosive warhead.

Where has the Hellfire missile been used on previous occasions?

  • In 2017, the ‘Ninja Missile’ was reportedly used to kill the then No. 2 leader of Al Qaeda, Abu Khayr Al Masri, in Syria. It was also used against other targets in Syria at around the same time. The damage caused to the vehicles which carried the targets, particularly the shredded roofs of cars, gave the first clues that a normal warhead was not used on the missile and that it had sharp blades. It has also been used against Taliban targets in Afghanistan in 2020 and again in 2022.

What is known about the other Hellfire missile variants?

  • Hellfire is actually an acronym for Heliborne, Laser, Fire and Forget Missile and it was developed in the US initially to target tanks from the Apache AH-64 attack helicopters. Later, the usage of these missiles spread to several other variants of helicopters and also ground and sea-based systems and drones.

THE GOVERNMENT SCHEMES AND INITIATIVES IN NEWS

5.REVISION SERIES: MISSION AMRIT SAROVAR

On 24th April 2022, Prime minister launched a mission to conserve water for the future which is known as Amrit Sarovar Mission. For celebrating the Azadi Ka Amrit Mahotsav, Amrit Sarovar aims to develop and rejuvenate 75 water bodies in each district of India. Under this mission, 50,000 water bodies of size of about an Acre will be created.

Amrit Sarovar Mission: Governing Bodies

The government has approached six ministries and departments which are mentioned below.

  • Department of Rural Development
  • Department of land resources
  • Department of Drinking water resources
  • Ministry of Panchayati Raj
  • Ministry of Forest
  • Environment and Climate change department.

The other institutions that were engaged with the mission are the Bhaskaracharya National Institute for Space Application and Geo-informatics (BISAG-N) as a technical partner.

The mission refocuses on various other missions like Mahatma Gandhi NREGA, XV Finance Commission Grants, PMKSY sub-schemes such as Watershed Development Component, and Har Khet Ko Pani. Also, the mission aims to increase the mobilisation of citizen and non-government resources for supplementing these efforts.

Amrit Sarovar Mission: Objectives

The government and secretary of all states have requested to complete the construction of the Amrit Sarovar as planned by the government of India. The government has ensured that there will be the use of technology in the construction of Amrit Sarovar. The states are requested to form the water structure for user’s association and impart required training for better development of the Amrit Sarovar. Till now, 12,241 sites are finalised for the construction of Amrit Sarovar out of which work has been started for 4,856 Amrit Sarovar.

Amrit Sarovar: Mission

  1. The mission is aimed it be completed by 15th August 2023.
  2. 50,000 Amrit Sarovar to be constructed all over the country.
  3. Every Amrit Sarovar will be approximate 1 acre with 10,000 cubic meters of water holding capacity.
  4. The focal point of the mission is people’s participation.
  5. The local freedom fighters, their family members, Martyr’s family members, Padma Shri Awardees and citizens of the local areas are the sites where Amrit Sarovar is to be constructed and they will be engaged in all stages of construction.
  6. On every Amrit Sarovar, Flag hosting will be done every Independence Day, 15 August.

THE PRELIMS PERSPECTIVE

6.ONE WORD A DAY – ASTROBEE

THE CONTEXT: Recently for the first time ever, two Astrobee robots have begun working independently on the International Space Station, side by side with humans.

THE EXPLANATION:

What is Astrobee?

Astrobee is NASA’s new free-flying robotic system.

  • According to NASA, “it will help astronauts reduce the time they spend on routine duties, leaving them more time to focus on the things that only humans can do.
  • Working autonomously or via remote control by astronauts, flight controllers or researchers on the ground, the robots are designed to complete tasks such as taking inventory, documenting experiments conducted by astronauts with their built-in cameras or working together to move cargo throughout the station.”
  • Astrobee also consists of a system that serves as a research platform that can be outfitted and programmed to conduct microgravity experiments. Thus, it will help to learn more about how robotics can benefit astronauts in space.

What are Honey, Queen and Bumble?

  • The three free-flying robots are named Honey, Queen, and Bumble. The robots are shaped like cubes 12.5 inches wide.
  • The Astrobee system consists of three cube-shaped robots, some software and a docking charging station used for recharging. They are about 32 centimetres wide.
  • The three robots propel themselves using electric fans that allow them to fly through the microgravity environment of the International Space Station.
  • They “look around” and navigate their surroundings using cameras and sensors.
  • All of the robots are equipped with a perching arm that allows them to grasp handrails to either conserve energy or grab and hold items.
  • When they are running low on charge, they can automatically return to their docking station to begin recharging.

What else you should know about Astrobee?

The Astrobee robots are built on the knowledge acquired from operating SPHERES (Synchronised Position Hold, Engage, Reorient, Experimental Satellite) robots which have been operating on the International Space Station for over a decade. Once fully commissioned, the Astrobee system will take over for SPHERES as the space station’s robotic test facility.

THE PRELIMS PRACTICE QUESTIONS

QUESTIONS OF THE DAY

Q.Consider the following statements with respect to UN peace keeping mission:

  1. UN peace keeping comprises of civilian, police and military personnel.
  2. In 2007, India became the first country to deploy an all-women contingent to a UN Peacekeeping Mission.

Which of the statements given above is/are correct?

a) only 1

b) only 2

c) Both 1 and 2

d) Neither 1 nor 2

 ANSWER FOR THE PRACTICE QUESTION

ANSWER: C

EXPLANATION:

  • UN peacekeepers come from all walks of life, with diverse cultural backgrounds and from an ever-growing number of Member States.
  • Peacekeepers are civilian, military and police personnel all working together. The roles and responsibilities of peacekeepers are evolving as peacekeeping mandates become more complex and multidimensional.
  • In 2007, India became the first country to deploy an all-women contingent to a UN peacekeeping mission. The Formed Police Unit in Liberia provided 24-hour guard duty and conducted night patrols.
  • Regenerative braking is an energy recovery mechanism that slows down a moving vehicle or object by converting its kinetic energy into a form that can be either used immediately or stored until needed. In this mechanism, the electric traction motor uses the vehicle’s momentum to recover energy that would otherwise be lost to the brake discs as heat.
  • Regenerative braking turns kinetic energy into electricity by reversing the process that drives the car forward.
  • In electric cars, the drivetrain is powered by a battery pack that powers a motor (or motors), creating torque–rotational force–on the wheels.
  • With regenerative braking, the energy from your spinning wheels is used to reverse the direction of electricity – from the electric motor(s) to the battery. All you have to do is remove your foot from the accelerator or, in some cases, press the brake pedal to activate regenerative braking. The electric motor not only acts as an electric generator, but it also helps slow your car down because energy is consumed by the wheels as they rotate the shaft in the electric motor.



Today’s Important Articles for Sociology (03-08-2022)

  1. Colonialism infected religion too READ MORE
  2. The paradox of secularism READ MORE



Today’s Important Articles for Geography (03-08-2022)

  1. Indian cheetah, from abundance to extinction READ MORE
  2. The US now calls water scarcity a national security issue: An expert explains how serious it can be READ MORE



Ethics Through Current Development (03-08-2022)

  1. TEACH RAMAYANA FOR ETHICS, AND MORAL VALUES READ MORE
  2. Don’t forget, you are not your shadow READ MORE
  3. Do not fear parting ways READ MORE



Today’s Important Articles for Pub Ad (03-08-2022)

  1. Money laundering is a serious issue. But SC verdict on PMLA is problematic READ MORE
  2. Efficacy of RTI Act is threatened by opacity, opposition from bureaucracy and lawmakers READ MORE



WSDP Bulletin (03-08-2022)

(Newspapers, PIB and other important sources)

Prelim and Main

  1. Remembering Pingali Venkayya, the architect of India’s national flag READ MORE
  2. Lok Sabha passes Wild Life (Protection) Amendment Bill, 2021. What it means. READ MORE
  3. Trade deficit soars past $31 billion in July READ MORE
  4. China threatens major military exercises around Taiwan over Pelosi visit READ MORE
  5. ‘Will launch targeted military operations’: China says after Pelosi lands in Taiwan READ MORE
  6. ‘Nearly 7,400 Sq Km of India’s Forest Land Under Encroachment’: Centre READ MORE
  7. Himalayan birds at higher risk of losing unique traits: Study READ MORE
  8. PM Modi meets Maldives President Solih, ink six pacts to broad-base ties READ MORE
  9. MGNREGA: Demand for jobs under rural employment scheme doubled in seven years, Centre data shows READ MORE

Main Exam

GS Paper- 1

  1. Colonialism infected religion too READ MORE
  2. The paradox of secularism READ MORE

GS Paper- 2

POLITY AND GOVERNANCE

  1. Money laundering is a serious issue. But SC verdict on PMLA is problematic READ MORE
  2. Efficacy of RTI Act is threatened by opacity, opposition from bureaucracy and lawmakers READ MORE

SOCIAL ISSUES

  1. Preventing scourge of child trafficking READ MORE

INTERNATIONAL ISSUES

  1. US-China rivalry not the same as US-Soviet. What India needs to watch out READ MORE
  2. Stalemate in India’s relations with China READ MORE

GS Paper- 3

ECONOMIC DEVELOPMENT

  1. Making sense of the ‘freebies’ issue: Most welfare schemes contribute to improving human development outcomes, also resulting in higher growth READ MORE
  2. A translation revolution for an inclusive, prosperous India READ MORE
  3. Expand GST base, reduce the compliance burden READ MORE
  4. Costs of delayed justice: The link with economic growth can’t be ignored READ MORE

ENVIRONMENT AND ECOLOGY

  1. Indian cheetah, from abundance to extinction READ MORE
  2. US now calls water scarcity a national security issue: An expert explains how serious it can be READ MORE

GS Paper- 4

ETHICS EXAMPLES AND CASE STUDY

  1. TEACH RAMAYANA FOR ETHICS, AND MORAL VALUES READ MORE
  2. Don’t forget, you are not your shadow READ MORE
  3. Do not fear parting ways READ MORE

Questions for the MAIN exam

  1. ‘Globalization was once for large multinational corporations, but digital platforms have enabled small businesses and entrepreneurs around the world to participate in global trade’. In the light of the statement, analyze the opportunities for India’s gig economy.
  2. The age of digital globalization is characterized by large imbalances and digital divides. In the light of the statement, critically analyse the recent steps taken by the Government of India to narrow the digital divide.

QUOTATIONS AND CAPTIONS

  • Victory attained by violence is tantamount to a defeat, for it’s momentary.
  • The acquisition of a vessel on a permanent basis is a logical next step to the passage of the Bill as also the revamp of the quite old Maitri research station.
  • Most welfare schemes contribute to improving human development outcomes, also resulting in higher growth.
  • Undermining the importance of these interventions of the Government by calling them ‘freebies’ exposes the elitism in our society, where the poor are seen as being unproductive and dependent on charity.
  • A translation revolution is blurring aesthetic, linguistic and political borders. This will raise inclusiveness, prosperity and soft power.
  • Increasing the quantity, quality, and speed of technologies and people that translate our languages are India’s infrastructure for inclusiveness, prosperity, and soft power.
  • It is imperative to ensure freedom of the press and democratic institutions, punish errant officials and maintain complete autonomy of the information commissions, in the interest of the people and the nation at large.
  • Globalization was once for large multinational corporations, but digital platforms have enabled small businesses and entrepreneurs around the world to participate in global trade.
  • India is poised to leapfrog into an era of digital globalization with more than half a billion internet users and a plethora of inhouse platforms, applications and digital services.
  • Religion provided a strong though not often discussed justification for colonialism.
  • Strict laws are urgently required to stop child trafficking as new methods of illegal trade challenge the existing system.
  • Raising the morality quotient has become a major concern today. It has become an important attribute of managerial quality gaining precedence over intelligence quotient.
  • Duty, sacrifice, integrity, values and righteousness is reflected in the behaviour of all leading characters.

50 WORD TALK

  • The Delhi excise policy mess reflects poorly on the AAP government. All businesses need a stable and predictable policy environment. Dramatic U-turns are unfair to businessmen who make investments and workers whose livelihoods depend on them. Pity Delhiites who have to go back to buying their booze from government dumps.

Things to Remember:

  • For prelims-related news, try to understand the context of the news and relate with its concepts so that it will be easier for you to answer (or eliminate) from given options.
  • Whenever any international place will be in news, you should do map work (marking those areas in maps and exploring other geographical locations nearby including mountains, rivers, etc. same applies to the national places.)
  • For economy-related news (banking, agriculture, etc.) you should focus on terms and how these are related to various economic aspects, for example, if inflation has been mentioned, try to relate with prevailing price rises, shortage of essential supplies, banking rates, etc.
  • For main exam-related topics, you should focus on the various dimensions of the given topic, the most important topics which occur frequently and are important from the mains point of view will be covered in ED.
  • Try to use the given content in your answer. Regular use of this content will bring more enrichment to your writing.



Day-258 | Daily MCQs | UPSC Prelims | HISTORY OF ANCIENT INDIA

[WpProQuiz 302]




TOPIC : UNDERSTANDING VACCINE TECHNOLOGIES

THE CONTEXT: Ever since the first vaccine was developed in 1796 to treat smallpox, several different methods have been created to develop successful vaccines. Today, those methods, known as vaccine technologies, are more advanced and use the latest technology to help protect the world from preventable diseases. Depending on the pathogen (a bacteria or virus) that is being targeted, different vaccine technologies are used to generate an effective vaccine. Just like there are multiple ways to develop a vaccine, they can also take on multiple forms—from needle injections and nasal sprays to oral doses, a more recent innovation. In total, there are six different vaccine technology platforms, each with its own benefits, and examples.

VACCINE

A vaccine is a biological preparation that improves immunity to a particular disease. A vaccine typically contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins or one of its surface proteins. Vaccines are like a training course for the immune system. They prepare the body to fight disease without exposing it to disease symptoms.

How a vaccine works – a general overview:

  • When viruses or bacteria (germs) invade our body, they attack and multiply. This invasion is called an infection, and the infection is what causes illness.
  • The first time the body encounters a germ, it can take several days for the immune system to make and use all the tools it needs to fight the infection.
  • After the infection has been eradicated, the immune system keeps a few “memory cells” that remember what it learned about how to protect against that disease.
  • If the body encounters the same virus or bacteria again, it will produce antibodies to attack the germ more quickly and efficiently.

TYPES OF VACCINES

LIVE-ATTENUATED VACCINES 

  • Live-attenuated vaccines contain live pathogens from either bacteria or a virus that have been “attenuated,” or weakened. Live-attenuated vaccines are produced by selecting strains of a bacteria or virus that still produce a robust enough immune response but that does not cause disease.
  • Attenuated viruses were one of the earliest methods of eliciting protective immune responses.
  • “Vaccinia, the first-ever vaccine which protects against smallpox, is actually where we get the term ‘vaccination’ from.”
  • Benefits: Because these types of vaccines contain a live pathogen, the immune system reacts very well to them and it will typically remember the pathogen for a very long time. Additional doses, or booster shots, are not always needed.
  • Examples: Measles, mumps, and rubella (MMR) vaccine, varicella (chickenpox) vaccine.

INACTIVATED VACCINES

  • Inactivated vaccines take a live pathogen and inactivate or kill it. When the vaccine is then introduced to a human through a shot, for example, the inactivated pathogen is strong enough to create an immune response, however, is incapable of causing disease. Multiple doses are often needed in order to build up immunity and offer full protection.
  • Benefits: Inactivated vaccines can be mass-produced and are relatively inexpensive to make.
  • Examples: Polio vaccine, influenza vaccine

SUBUNIT VACCINES 

  • Subunit vaccines are made from a piece of a pathogen, not the whole organism, so they do not contain any live pathogens. Some important subunit vaccines are polysaccharide vaccines, conjugate vaccines, and protein-based vaccines.
  • Polysaccharide vaccines target an immune response to pathogenic bacteria that are encased in a layer of sugar. This means they help you make protective responses against the surface of the bacteria, allowing your body to kill the bacteria. These do not work and therefore are not used for children under the age of 2 years.
  • Conjugate vaccines are the same in that they have a polysaccharide component, but that sugar is stuck to a protein so your immune system will respond to the sugar on the bacteria better. They also help your body remember the bacteria better, so if you get infected in the future, the immune response will be better. Importantly, these vaccines do work in children under 2 years of age.
  • Protein-based vaccines allow you to make a protective response against a protein on the surface of a virus, against a protein on the surface of a bacteria, or against a secreted toxin. In this case, the immune response is against the protein components of the bacteria or virus, not the sugar coat. Certain proteins on the surface of bacteria or viruses help the pathogen cause disease, so inducing an immune response against them can help the body fight against the infection or the effects of the toxin.
  • Subunit vaccines can be made one of two ways –  from the original pathogen or recombinantly. Recombinant vaccines use another organism to make the vaccine antigen.
  • Benefits: Subunit vaccines only contain pieces of a pathogen, not the whole organism, so they cannot make you sick or cause infection. This makes them suitable for people who should not receive “live” vaccines, such as young children, older people, and immunocompromised people.
  • Examples: Haemophilus influenzae type B (Hib) vaccine (conjugate), pneumococcal vaccine (polysaccharide or conjugate), shingles vaccine (recombinant protein), hepatitis B (recombinant protein), acellular pertussis, MenACWY (conjugate).

TOXOID VACCINES

  • Toxoid vaccines use inactivated toxins to target the toxic activity created by the bacteria, rather than targeting the bacteria itself. The goal of toxoid vaccines is to give people a way to neutralize those toxins with antibodies through vaccination.
  • Benefits: Toxoid vaccines are especially good at preventing certain toxin-mediated diseases such as tetanus, diphtheria, and pertussis. Booster shots are typically recommended every 10 years or so.
  • Examples: Tetanus vaccine, diphtheria vaccine

VIRAL VECTOR VACCINES

  • Viral vector vaccines use a harmless virus to deliver to the host cells the genetic code of the antigen you want the immune system to fight. They are basically a gene delivery system. In doing so, information about the antigen is delivered, which triggers the body’s immune response.
  • Benefits: Viral vector vaccines usually trigger a strong immune response. Typically, only one dose of the shot is needed to develop immunity. Boosters may be needed to maintain immunity.
  • Examples: Ebola vaccine, COVID-19 vaccine (AstraZeneca and Johnson & Johnson)

MESSENGER RNA (MRNA) VACCINES 

  • One of the newest and most exciting areas in vaccine technology is the use of mRNA vaccines. Unlike conventional vaccines—which can take many months or even years to cultivate—mRNA vaccines can be developed quickly using the pathogen’s genetic code. mRNA is likely to be at least one of the waves of the future for vaccines.
  • When an mRNA vaccine is delivered, the RNA material teaches our body how to make a specific type of protein that is unique to the virus but does not make the person sick. The protein triggers an immune response, which includes the generation of antibodies that recognize the protein. That way, if a person is ever exposed to that virus in the future, the body would have the tools (antibodies) to fight against it.
  • Benefits: It is a very powerful technique to be able to create a lot of a vaccine fast. The benefit is that the technology is very adaptable. We can potentially go in and change the mRNA in the formulation to target a new antigen and can make a lot of high-quality vaccine material relatively quickly.
  • Examples: Pfizer-BioNTech COVID-19 vaccine

mRNA VACCINE AND CONVENTIONAL VACCINE

CONVENTIONAL VACCINE

PRODUCTION TIME

  • Most vaccines against viral diseases are made from viruses grown in chicken eggs or mammalian cells.
  • The process of collecting the viruses, adapting them to grow in the lab, and shipping them around the world can take months and is complex.
  • For newly emerging viruses like SARS-CoV-2, for which a new vaccine is needed as quickly as possible, these steps may slow down development.

BIOSAFETY

  • Growing large quantities of viruses to make each batch of vaccines creates potential hazards.

IMMUNE RESPONSE 

  • The antigen (a piece of the virus) is injected into the body. Upon recognizing the antigen, the immune system produces specific antibodies in preparation for the next time the body encounters the pathogen.

FLEXIBILITY

  • Each new vaccine requires a bespoke production process, including complex purification and testing.

Transport and storage temperature

  • Various vaccines have different temperature requirements, and generally can be stored in common refrigerators.

mRNA VACCINE

PRODUCTION TIME

  • The RNA (which encodes an antigen of the infectious agent) is made from a DNA template in the lab.
  • The DNA can be synthesized from an electronic sequence that can be sent across the world in an instant by computer. Currently, it takes about a week to generate an experimental batch of an RNA vaccine.

BIOSAFETY

  • No virus is needed to make a batch of an RNA vaccine.
  • Only small quantities of viruses are used for gene sequencing and vaccine testing.

IMMUNE RESPONSE 

  • The RNA is injected into the body and enters cells, where it provides instructions to produce antigens. The cell then presents the antigens to the immune system, prompting T-cell and antibody responses that can fight the disease.

FLEXIBILITY

  • It is anticipated that the production process for RNA vaccines may be scaled and standardized; potentially enabling the replacement of the sequence encoding the target protein of interest for a new vaccine, with minimal changes to the vaccine production process.

Transport and storage temperature

  • Requires sub-zero temperature which makes them hard to transport and make available at all places. Generally -20 to -70 degree celsius.

ADMINISTRATION OF VACCINES

ORAL VACCINE (PO)

The oral vaccine is administered through drops to the mouth. Rotavirus vaccine (RV1 [Rotarix], RV5 [RotaTeq]) is the only routinely recommended vaccine administered orally only. Rotavirus vaccine should never be injected. Though Polio vaccine is given in two ways: an inactivated poliovirus given by injection and a weakened poliovirus given by mouth.

INTRANASAL ROUTE (NAS) 

The intranasal vaccine is administered into each nostril using a manufacturer-filled nasal sprayer. Live, attenuated influenza (LAIV [FluMist]) vaccine is administered by the intranasal route.

SUBCUTANEOUS ROUTE (SUB CUT)

Subcutaneous injections are administered into the fatty tissue found below the dermis and above muscle tissue.

INTRAMUSCULAR ROUTE (IM)

Intramuscular injections are administered into the muscle through the skin and subcutaneous tissue. The recommended site is based on age.  Use the correct needle length and gauge based on the age, weight, and gender of the recipient.

Previous Year Questions:

Q1.UPSC CES PRE – 2022

In the context of vaccines manufactured to prevent the COVID-19 pandemic, consider the following statements:

  1. The Serum Institute of India produced a COVID-19 vaccine named Covishield using an mRNA platform.
  2. Sputnik V vaccine is manufactured using vector-based platform.
  3. COVAXIN is an inactivated pathogen-based vaccine.

Which of the statements given above are correct?

a) 1 and 2 only

b) 2 and 3 only

c) 1 and 3 only

d) 1, 2 and 3

Q2.UPSC CDS 1 – APRIL 2022

Consider the following pair of vaccines and category/type:

  1. Covaxin – Inactivated pathogen based vaccine.
  2. Covishield – mRNA vaccine.
  3. Sputnik V – Viral vector based vaccine.

Which of the pairs given above is/are correct?

a) 1 only

b) 2 and 3 only

c) 1 and 3 only

d) 1, 2 and 3

 Mains Practice Question:

  1. Explain the various technologies used for making vaccines.
  2. Write a note mRNA vaccine and how it scores over the conventional vaccines.

    COVID VACCINES APPROVED FOR USE IN INDIA

    VACCINE COMPANY TYPE ADMINISTRATION TYPE
    1. Corbevax Biological E Ltd Protein Subunit INTRAMUSCULAR ROUTE (IM)
    2. COVOVAX Serum Institute of India Protein Subunit INTRAMUSCULAR ROUTE (IM)
    3. ZyCov-D Zydus Cadila DNA WORLD’S FIRST NEEDLE-FREE PLASMID DNA VACCINE.
    4. GEMCOVAC Gennova Biopharmaceuticals Limited RNA INTRAMUSCULAR ROUTE (IM)
    5. Spikevax Moderna RNA INTRAMUSCULAR ROUTE (IM)
    6. Sputnik Light Gamaleya Non Replicating Viral Vector INTRAMUSCULAR ROUTE (IM)
    7. Sputnik V Gamaleya Non Replicating Viral Vector INTRAMUSCULAR ROUTE (IM)
    8. Ad26.COV2.S Johnson & Johnson Non Replicating Viral Vector INTRAMUSCULAR ROUTE (IM)
    9. Vaxzevria Oxford/AstraZeneca Non Replicating Viral Vector INTRAMUSCULAR ROUTE (IM)
    10. Covishield (Oxford/ AstraZeneca formulation) Serum Institute of India Non Replicating Viral Vector INTRAMUSCULAR ROUTE (IM)
    11. Covaxin Bharat Biotech Inactivated INTRAMUSCULAR ROUTE (IM)